![]() ![]() ![]() The groups of most enriched biological processes were manually circled and labeled. Sizes of the circles relate to the number of genes involved in the biological processes and colors refer to p-values. (B,C) The networks of biological processes enriched among genes dysregulated in preeclampsia and co-expressed with hub factors in M1 ( ZNF554) and M2 ( BCL6) modules were visualized with the BINGO module of Cytoscape. BCL6 and ARNT2 had the most correlation with FLT1. ![]() Within the M2 (red) module, BCL6, BHLHE40, and ARNT2 transcription regulatory genes were correlated most strongly with predominantly placenta-expressed genes. ESRRG and ZNF554 had the most correlation with CSH1 and HSD11B2, genes strongly implicated in fetal growth. Within the M1 (green) module, ESRRG, POU5F1, and ZNF554 transcription regulatory genes correlated most strongly with predominantly placenta-expressed genes. (A) Co-expression matrix of transcription regulatory genes and predominantly placenta-expressed genes in the M1 and M2 modules. Figure S1: Hub transcription regulatory genes in the M1 and M2 modules and their interaction network. ![]()
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